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1

The Wittig olefination reaction and modifications involving phosphoryl-stabilized carbanions. Stereochemistry, mechanism, and selected synthetic aspects

Maryanoff, Bruce E., Reitz, Allen B.

Journal:

Chemical Reviews

Year:

1989

Language:

english

File:

PDF, 9.43 MB

english, 1989

2

Stereochemistry and mechanism of the Wittig reaction. Diasteromeric reaction intermediates and analysis of the reaction course

Maryanoff, Bruce E., Reitz, Allen B., Mutter, Martin S., Whittle, Robert R., Olofson, R. A.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 2.98 MB

english, 1986

3

Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-.beta.-D-fructopyranose sulfamate and related compounds

Maryanoff, Bruce E., Nortey, Samuel O., Gardocki, Joseph F., Shank, Richard P., Dodgson, Susanna P.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.19 MB

english, 1987

4

Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate

Richard P. Shank, Bruce E. Maryanoff

Journal:

CNS Neuroscience & Therapeutics

Year:

2008

Language:

english

File:

PDF, 340 KB

english, 2008

5

Structure−Activity Studies on Anticonvulsant Sugar Sulfamates Related to Topiramate. Enhanced Potency with Cyclic Sulfate Derivatives

Maryanoff, Bruce E., Costanzo, Michael J., Nortey, Samuel O., Greco, Michael N., Shank, Richard P., Schupsky, James J., Ortegon, Marta P., Vaught, Jeffry L.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 637 KB

english, 1998

6

Selective reduction of aliphatic ketones and aldehydes to hydrocarbons with sodium cyanoborohydride and p-toluenesulfonyl hydrazide in dimethylformamide-sulfolane

Hutchins, Robert O., Maryanoff, Bruce, Milewski, Cynthia

Journal:

Journal of the American Chemical Society

Year:

1971

Language:

english

File:

PDF, 288 KB

english, 1971

7

Cobalt-Mediated Macrocyclizations. Facile Synthesis of 2-Oxo Pyridinophanes via [2 + 2 + 2] Cycloaddition of α,ω-Diynes and Isocyanates †

Boñaga, Llorente V. R., Zhang, Han-Cheng, Gauthier, Diane A., Reddy, Indrasena, Maryanoff, Bruce E.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

8

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures1

Abdel-Magid, Ahmed F., Carson, Kenneth G., Harris, Bruce D., Maryanoff, Cynthia A., Shah, Rekha D.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 412 KB

english, 1996

9

NMR three-dimensional solution structure of the serine protease inhibitor cyclotheonamide A

Patricia A. McDonnell, Gary W. Caldwell, Gregory C. Leo, Brent L. Podlogar, Bruce E. Maryanoff

Journal:

Year:

1997

Language:

english

File:

PDF, 99 KB

english, 1997

10

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

Richard P. Shank, Joseph F. Gardocki, Jeffry L. Vaught, Coralie B. Davis, James J. Schupsky, Robert B. Raffa, Susanna J. Dodgson, Samuel O. Nortey, Bruce E. Maryanoff

Journal:

Year:

1994

Language:

english

File:

PDF, 1.03 MB

english, 1994

11

Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality

Bruce E. Maryanoff, Michael J. Costanzo

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

12

Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships

Maryanoff, Bruce E., McComsey, David F., Gardocki, Joseph F., Shank, Richard P., Costanzo, Michael J., Nortey, Samuel O., Schneider, Craig R., Setler, Paulette E.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 3.07 MB

english, 1987

13

Corrigendum to “Bridged bicyclic vasopressin receptor antagonists with V2-selective or dual V1a/V2 activity”: [Bioorg. Med. Chem. Lett. 12 (2002) 3081]

Alexey B. Dyatkin, William J. Hoekstra, Dennis J. Hlasta, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T. Demarest, Joseph W. Gunnet, William Hageman, Richard Look, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 207 KB

english, 2004

14

Potency variation of small-molecule chymase inhibitors across species

Jukka Kervinen, Carl Crysler, Shariff Bayoumy, Marta C. Abad, John Spurlino, Ingrid Deckman, Michael N. Greco, Bruce E. Maryanoff, Lawrence de Garavilla

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 359 KB

english, 2010

15

DELVING INTO THE WITTIG REACTION-STEREOCHEMISTRY AND MECHANISM. STEREOCHEMICAL IDIOSYNCRASIES AND MECHANISTIC IMPLICATIONS 1

Maryanoff, Bruce E., Reitz, Allen B.

Journal:

Phosphorous and Sulfur and the Related Elements

Year:

1986

Language:

english

File:

PDF, 1.05 MB

english, 1986

16

Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator

Maryanoff, Bruce E., Reitz, Allen B., Tutwiler, Gene F., Benkovic, Stephen J., Benkovic, Patricia A., Pilkis, Simon J.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 448 KB

english, 1984

17

Selective deoxygenation of ketones and aldehydes including hindered systems with sodium cyanoborohydride

Hutchins, Robert O., Milewski, Cynthia A., Maryanoff, Bruce E.

Journal:

Journal of the American Chemical Society

Year:

1973

Language:

english

File:

PDF, 831 KB

english, 1973

18

Complexation of calcium by the synthetic ionophore McN-4308, [2-(4-(diphenylmethy)-1-piperidinyl)-2-oxoethoxy]acetic acid. Crystal and molecular structure of the free acid and of the calcium complex

Van Roey, Patrick, Smith, G. David, Duax, William L., Umen, Michael J., Maryanoff, Bruce E.

Journal:

Journal of the American Chemical Society

Year:

1982

Language:

english

File:

PDF, 1.12 MB

english, 1982

19

Carbonic Anhydrase-II Inhibition. What are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate?

Maryanoff, Bruce E., McComsey, David F., Lee, Jung, Smith-Swintosky, Virginia L., Wang, Yuanping, Minor, Lisa K., Todd, Matthew J.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 102 KB

english, 2008

20

Drug discovery and the medicinal chemist

Maryanoff, Bruce E

Journal:

Future Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 413 KB

english, 2009

21

Phenotypic Assessment and the Discovery of Topiramate

Maryanoff, Bruce E.

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 262 KB

english, 2016

22

ChemInform Abstract: THIABENZENES PART 2, EVIDENCE FOR AN YLIDE MODEL

STACKHOUSE, JOSEPH, MARYANOFF, BRUCE E., SENKLER, G. H. JUN., MISLOW, KURT

Journal:

Chemischer Informationsdienst

Year:

1974

File:

PDF, 187 KB

1974

23

Structural Studies on McN-5652-X (I), a High-Affinity Ligand for the Serotonin Transporter in Mammalian Brain.

Bruce E. Maryanoff, David F. McComsey, Rina K. Dukor, Laurence A. Nafie, Teresa B. Freedman, Xiaolin Cao, Victor W. Day

Journal:

Year:

2003

File:

PDF, 60 KB

2003

24

Photoactivatable peptides based on BMS-197525: A potent antagonist of the human thrombin receptor (PAR-1)

John T. Elliott, William J. Hoekstra, Bruce E. Maryanoff, Glenn D. Prestwich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 425 KB

english, 1999

25

Synthesis, resolution, and absolute configuration of novel tricyclic benzodiazepines

Jay M. Matthews, Alexey B. Dyatkin, Mary Evangelisto, Diane A. Gauthier, Leonard R. Hecker, William J. Hoekstra, Fuqiang Liu, Brenda L. Poulter, Kirk L. Sorgi, Bruce E. Maryanoff

Journal:

Tetrahedron: Asymmetry

Year:

2004

Language:

english

File:

PDF, 467 KB

english, 2004

26

Carbohydrate biguanides as potential hypoglycemic agents.

Reitz, Allen B., Tuman, Robert W., Marchione, Carol S., Jordan, Alfonzo D., Bowden, Charles R., Maryanoff, Bruce E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 982 KB

english, 1989

27

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions

Maryanoff, Bruce E., Greco, Michael N., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A., Nicolaou, K. C., Liu, Aijun, Brungs, Peter H.

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 2.71 MB

english, 1995

28

Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin

Maryanoff, Bruce E., McComsey, David F., Costanzo, Michael J., Setler, Paulette E., Gardocki, Joseph F., Shank, Richard P., Schneider, Craig R.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 470 KB

english, 1984

29

Solid-Phase Synthesis of Arginine-Containing Peptides by Guanidine Attachment to a Sulfonyl Linker

Zhong, H. Marlon, Greco, Michael N., Maryanoff, Bruce E.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 112 KB

english, 1997

30

Conformational analysis of 2-phospha-1,3-dithiacyclohexanes. Further evidence for the general axial preference of phosphorus substituents in saturated six-membered rings

Hutchins, Robert O., Maryanoff, Bruce E.

Journal:

Journal of the American Chemical Society

Year:

1972

Language:

english

File:

PDF, 443 KB

english, 1972

31

Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers

McKenna, John I., Schlicksupp, Ludwig, Natale, Nicholas R., Willett, Roger D., Maryanoff, Bruce E., Flaim, Stephen F.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 513 KB

english, 1988

32

Chiroptical properties and absolute configuration of pyrroloisoquinoline antidepressants

Bruce E. Maryanoff, David F. McComsey, J. Cymerman Craig

Journal:

Year:

1998

Language:

english

File:

PDF, 87 KB

english, 1998

33

The wittig reaction of non-stabilized phosphorus ylides and aromatic aldehydes. Studies on erythro and threo β-hydroxyphosphonium salts and the promotion of stereochemical drift by synergism between diastereomers

Bruce E. Maryanoff, Allen B. Reitz

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 293 KB

english, 1985

34

Bridged bicyclic vasopressin receptor antagonists with V2-Selective or dual V1a/V2 activity

Alexey B Dyatkin, William J Hoekstra, Dennis J Hlasta, Patricia Andrade-Gordon, Lawrence de Garavilla, Keith T Demarest, Joseph W Gunnet, William Hageman, Richard Look, Bruce E Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002

35

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN

David F. McComsey, Leonard R. Hecker, Patricia Andrade-Gordon, Michael F. Addo, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 306 KB

english, 1999

36

The effect of arabinose 1,5-bisphosphate on rat hepatic 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase

Simon J. Pilkis, Molly M. McGrane, Paul D. Kountz, M. Raafat El-Maghrabi, Jo Pilkis, Bruce E. Maryanoff, Allen B. Reitz, Stephen J. Benkovic

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 465 KB

english, 1986

37

Mimicry of High-Density Lipoprotein: Functional Peptide–Lipid Nanoparticles Based on Multivalent Peptide Constructs

Zhao, Yannan, Imura, Tomohiro, Leman, Luke J., Curtiss, Linda K., Maryanoff, Bruce E., Ghadiri, M. Reza

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

38

Stereocontrol between Remote Atom Centers in Acyclic Substrates. Anti Addition of Hydride to 1,5-, 1,6-, and 1,7-Hydroxy Ketones †

Zhang, Han-Cheng, Harris, Bruce D., Costanzo, Michael J., Lawson, Edward C., Maryanoff, Cynthia A., Maryanoff, Bruce E.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 515 KB

english, 1998

39

Additions and Corrections - Stereoselective Synthesis and Biological Activity of β -and α-D-Arabinose 1,5-Diphosphate: Analogues of a Potent Metabolic Regulator

Maryanoff, Bruce, Reitz, Allen, Tutwiler, Gene, Benkovic, Stephen, Benkovic, Patricia, Pilkis, Simon

Journal:

Journal of the American Chemical Society

Year:

1985

Language:

english

File:

PDF, 96 KB

english, 1985

40

Doubly connected phosphorus cations. Diaminophosphenium ions from 2-R-2-phospha-1,3-diazacyclohexanes

Maryanoff, Bruce E., Hutchins, Robert O.

Journal:

Journal of Organic Chemistry

Year:

1972

Language:

english

File:

PDF, 809 KB

english, 1972

41

Synthesis of hydroxylated derivatives of topiramate, a novel antiepileptic drug based on d-fructose: Investigation of oxidative metabolites

Samuel O. Nortey, Wu-Nan Wu, Bruce E. Maryanoff

Journal:

Carbohydrate Research

Year:

1997

Language:

english

File:

PDF, 796 KB

english, 1997

42

Remote acyclic diastereocontol involving a bicyclic metal chelate. High 1,5 asymmetric induction in the hydride reduction of δ-hydroxy ketones

Han-Cheng Zhang, Michael J. Costanzo, Bruce E. Maryanoff

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 393 KB

english, 1994

43

Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif

Michael N. Greco, Eugene T. Powell, Leonard R. Hecker, Patricia Andrade-Gordon, Jack A. Kauffman, Joan M. Lewis, Venkatapathy Ganesh, Alexander Tulinsky, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 280 KB

english, 1996

44

Heteroaromatic N-oxide rearrangements. Reinvestigation of 1,3 tosyloxy migration in the reaction of isoquinoline N-oxide with tosyl chloride

Bruce E. Maryanoff, Han-Cheng Zhang, Allen B. Reitz, Gregory C. Leo, William J. Jones

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 288 KB

english, 1993

45

CHARACTERIZATION OF RWJ-351647, A NOVEL NONPEPTIDE VASOPRESSIN V2 RECEPTOR ANTAGONIST

Joseph W Gunnet, Jay M Matthews, Bruce E Maryanoff, Lawrence De Garavilla, Patricia Andrade-Gordon, Bruce Damiano, William Hageman, Richard Look, Paul Stahle, Anthony J Streeter, Pamela G Wines, Keith

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

46

Potential Anxiolytic Agents. Pyrido[1,2-a]benzimidazoles: A New Structural Class of Ligands for the Benzodiazepine Binding Site on GABA-A Receptors

Maryanoff, Bruce E., Ho, Winston, McComsey, David F., Reitz, Allen B., Grous, Philip P., Nortey, Samuel O., Shank, Richard P., Dubinsky, Barry, Taylor, Russell J. Jr., Gardocki, Joseph F.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 536 KB

english, 1995

47

3-Aza-Cope Rearrangement of Quaternary N -Allyl Enammonium Salts. Stereospecific 1,3 Allyl Migration from Nitrogen to Carbon on a Tricyclic Template

McComsey, David F., Maryanoff, Bruce E.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 176 KB

english, 2000

48

Corrections to Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif

Lu, Tianbao, Markotan, Thomas, Ballentine, Shelley K., Giardino, Edward C., Spurlino, John, Crysler, Carl S., Brown, Kathryn, Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Shukla, Umesh,

Journal:

Journal of Medicinal Chemistry

Year:

2010

File:

PDF, 548 KB

2010

49

One-step synthesis of optically pure 1,2-ethanobis(sulfoxides)and phosphine oxides via the copper-promoted oxidative dimerization of chiral sulfinyl and phosphinyl carbanions

Maryanoff, Cynthia A., Maryanoff, Bruce E., Tang, Reginald., Mislow, Kurt.

Journal:

Journal of the American Chemical Society

Year:

1973

Language:

english

File:

PDF, 301 KB

english, 1973

50

Phosphorus-containing cyclohexanes. Nuclear magnetic resonance studies and conformational analysis of 1,3,2-dithiaphosphorinanes

Maryanoff, Bruce E., McPhail, Andrew T., Hutchins, Robert O.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 1.82 MB

english, 1981

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